Basophil Activation Test Using Recombinant Allergens: Highly Specific Diagnostic Method Complementing Routine Tests in Wasp Venom Allergy
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منابع مشابه
Basophil Activation Test Using Recombinant Allergens: Highly Specific Diagnostic Method Complementing Routine Tests in Wasp Venom Allergy
BACKGROUND Skin testing can expose allergic subjects to potential systemic reactions, sensitization against unrelated proteins, and increased risk of future sting reactions. Therefore the continuous improvement of in vitro diagnostic methods is desirable. Recombinant allergens have been shown to improve the sensitivity of specific IgE (sIgE) detection in vitro whilst no data is available regard...
متن کاملIn vitro basophil activation using CD63 expression in patients with bee and wasp venom allergy.
The diagnosis of insect venom allergy and the indication for specific immunotherapy is based on history, skin tests and demonstration of hymenoptera venom-specific IgE-antibodies. Cellular tests can add useful information but the role of basophil activation tests for the different venoms has to be elucidated further. We evaluated positive reactions in a basophil activation test using CD63 expre...
متن کاملBasophil Activation Tests: A Diagnostic Break-Through in Opiate Allergy
416 http://e-aair.org We have read the manuscript about codeine (3-methylmorphine) anaphylaxis by Yoo et al. with great interest and would like to take the opportunity to raise some issues and communicate our experience. As recently reviewed, despite their frequent and ubiquitous use, genuine IgE-mediated allergy to opiates remains exceedingly rare. Also, correct diagnosis is not straightforwar...
متن کاملBasophil activation test in the diagnosis and monitoring of mastocytosis patients with wasp venom allergy on immunotherapy.
BACKGROUND There is need for an accurate diagnostic test in mastocytosis patients with wasp venom allergy (WVA) and monitoring of these patients during immunotherapy (IT). In this study, we aimed to evaluate sensitivity and specificity of the Basophil Activation Test (BAT) as a diagnostic and monitoring test in patients with mastocytosis and WVA. METHODS Seventeen patients with mastocytosis a...
متن کاملImportance of basophil activation testing in insect venom allergy
BACKGROUND Venom immunotherapy (VIT) is the only effective treatment for prevention of serious allergic reactions to bee and wasp stings in sensitized individuals. However, there are still many questions and controversies regarding immunotherapy, like selection of the appropriate allergen, safety and long term efficacy. METHODS Literature review was performed to address the role of basophil a...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0108619